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US 4,303,789 AGranted
2-Amino-4-(substituted hydrazino)-6-imino pyrimidines
AssigneeBurroughs Wellcome Co.
InventorsRobert W. Morrison, Jr., William R. Mallory, Virgil L. Styles
Life of this patent
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Abstract
The present invention provides pyrimido (4,5-c) pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido (4,5-c)pyridazines of this invention are useful due to their activity as inhibitors of dihydropteroic and biosynthesis.
Claims1
A compound of the formula (VII):
- ##STR20## wherein R.sup.2 is lower alkyl, lower acyloxymethyl, phenyl, benzyl, benzyl substituted in the phenyl ring with one or more nitro or lower alkoxy, phenacyl, phenacyl substituted in the phenyl ring with one or more hydroxy or lower alkoxy, CH.sub.2 OCOR.sup.4 where R.sup.4 is lower alkyl, indolyl, indolymethyl, CH(CN)CH.sub.2 C.sub.6 H.sub.5, CH(CN)CH.sub.2 C.sub.6 H.sub.5 substituted in the phenyl ring with one or more more lower alkoxy, CH(Y)CO.sub.2 Z or CH.sub.2 CH.sub.2 CO.sub.2 Z in which Y is a hydrogen atom or lower alkly and Z is hydrogen or C.sub.1-4 alkyl, and R.sup.3 is lower alkyl.
Dependencies are inferred from the claim text.