N-Propionylsarcosineanilides, process for their preparation, and pharmaceutical compositions containing them

Abstract

The invention provides N-propionylsarcosineanilides of the formula: ##STR1## wherein n is an integer of 1 to about 3 and the substituent A which can be the same or different when n is greater than 1 is selected from the group consisting of trifluoromethyl; halogen; nitro; acetyl; a straight-chain or branched alkyl group having 1 to 4 carbon atoms; a straight-chain or branched alkoxy group having 1 to 4 carbon atoms; a straight-chain or branched alkylmercapto group having 1 to 7 carbon atoms; a substituted alkylmercapto group of the formula: ##STR2## wherein n is an integer of 1 or 2, R.sub.1 can represent hydrogen and methyl, and R.sub.2 can represent hydroxyl, and an amino group of the formula: --NR.sub.6 R.sub.7 V wherein R.sub.6 can represent hydrogen, and methyl, and R.sub.7 can represent methyl, substituted benzyl, and R.sub.6 and R.sub.7, together with the nitrogen, can constitute a substituted pyrrolidine ring; a sulphonyl group of the formula: --SO.sub.2 R.sub.3 III wherein R.sub.3 can represent amino, and alkyl of 1 to 3 carbon atoms; or an aminoethoxycarbonyl group of the formula: ##STR3## wherein R.sub.4 and R.sub.5 which can be the same or different can represent hydrogen, methyl, and ethyl; and the pharmaceutically acceptable salts thereof. These compounds may be made from N-propionylsarcosine and the corresponding substituted anilines. They have central vaso-active properties, are useful in controlling metabolism, inhibit the aggregation of thrombocytes, can be used for the treatment of the cerebroischaemic and atrophic type, and have tranquillizing properties.

Dependencies are inferred from the claim text.