Butyrophenone compounds
AssigneeSumitomo Chemical Company, Limited
InventorsKikuo Sasajima, Keiichi Ono, Masaru Nakao, Hisao Yamamoto
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AssigneeSumitomo Chemical Company, Limited
InventorsKikuo Sasajima, Keiichi Ono, Masaru Nakao, Hisao Yamamoto
Estimating the term…
Butyrophenone compounds having excellent psychotropic activities represented by the formula: ##STR1## wherein R.sup.1 is a halogen atom, R.sup.2 is a lower alkyl group, and Z is a group of either one of the formulae: ##STR2## (wherein the dotted line indicates the optional presence of an additional single bond linkage, R.sup.3 is a hydrogen atom or a hydroxyl group but only when said additional single bond linkage is not present and R.sup.4 is a hydrogen atom or a phenyl or benzyl group optionally substituted with one or two substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy and trifluoromethyl on the benzene ring (except monohalophenyl)), ##STR3## (wherein the dotted line indicates the optional presence of an additional single bond linkage, R.sup.5 is a hydrogen atom or a lower alkyl group and R.sup.6 and R.sup.7 are each a hydrogen atom, a halogen atom or a lower alkyl group), ##STR4## (wherein R.sup.8 is a hydrogen atom or a lower alkyl group and R.sup.9 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group), ##STR5## (wherein R.sup.10 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group), or ##STR6##
1-[.gamma.-(2-Lower alkyl-4-halobenzoyl)propyl]-4-(3-trifluoromethylphenyl)-4-hydroxypiperidin e, or a pharmaceutically acceptable acid addition salt thereof.
1-[.gamma.-(2-Methyl-4-fluorobenzoyl)propyl]-4-(3-trifluorom ethylphenyl)-4-hydroxypiperidine, or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.