Benzyl-tetrahydro-2,4-dihydroxy-1,6-naphthyridine-3 carboxylic acid type antiallergy agents
AssigneeAmerican Home Products Corporation
InventorStanley C. Bell
Life of this patent
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Abstract
1,6-Naphthyridine derivatives of the formula: ##STR1## in which R.sup.1 and R.sup.2 are, independently, hydrogen, alkyl of 1 to 3 carbon atoms, halo, or trifluoromethyl; R.sup.3 is hydrogen, alkyl of 1 to 6 carbon atoms or a pharmaceutically acceptable metal or amine cation; and n is one of the integers 1, 2 or 3; or a pharmaceutically acceptable salt thereof and pharmaceutical compositions containing those compounds are useful as antiallergy agents effective prophylactically to relieve the symptoms manifest in atopic immediate sensitivity in mammals.
Claims12
A compound of the formula:
- ##STR6## in which R.sup.1 and R.sup.2 are, independently, hydrogen, alkyl of 1 to 3 carbon atoms, halo or trifluoromethyl;
- and
- n is one of the integers 1, 2 or 3;
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition which comprises an antiallergic amount of a compound of the formula:
- ##STR8## in which R.sup.1 and R.sup.2 are, independently, hydrogen, alkyl of 1 to 3 carbon atoms, halo or trifluoromethyl;
- R.sup.3 is hydrogen, alkyl of 1 to 6 carbon atoms or a pharmaceutically acceptable metal or amine cation and
- n is one of the integers 1, 2 or 3
- and a pharmaceutical carrier.
A method for prophylactically treating a sensitized mammal to prevent the symptoms manifest in an immediate hypersensitivity reaction between reaginic type antibodies and an antigen which comprises administering to said mammal an effective amount of a compound of the fomrula:
- ##STR9## in which R.sup.1 and R.sup.2 are, independently, hydrogen, alkyl of 1 to 3 carbon atoms, halo, or trifluoromethyl;
- R.sup.3 is hydrogen, alkyl of 1 to 6 carbon atoms or a pharmaceutically acceptable metal or amine cation;
- and
- n is one of the integers 1, 2 or 3;
- and a pharmaceutical carrier.
Dependencies are inferred from the claim text.