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AssigneeEgyt Gyogyszervegyeszeti Gyar
InventorsEdit Berenyi nee Poldermann, Eniko Szirt nee Kiszelly, Peter Gorog, Lujza Petocz, Ibolya Kosoczky, Agnes Kovacs nee Palotai, Gabriella rmos nee Lassu
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The invention relates to novel pyrazolo[1,5-c]quinazoline derivatives of the general formula I ##STR1## wherein R represents a hydrogen atom, a C.sub.1-4 alkyl group or an acyl group, R.sub.1 represents a hydrogen atom, a C.sub.1-12 alkyl group, a C.sub.3-8 cycloalkyl group, a C.sub.2-4 alkenyl group, an aralkyl group, wherein the alkyl group has 1 to 4 carbon atoms, a phenylalkenyl group, wherein the alkenyl group has 2 to 4 carbon atoms, furthermore a carboxy group or a phenyl group optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxy, C.sub.1-4 alkoxy, nitro or di(C.sub.1-4 alkyl)amino groups, or R and R.sub.1 may form together a valence bond, R.sub.2 represents a hydrogen atom, a C.sub.1-4 alkyl or a phenyl group, or R.sub.1 and R.sub.2 may form together a C.sub.2-7 alkylene group, R.sub.3 represents a nitro group, an amino group, an alkylamino group, a dialkylamino group, wherein the alkyl groups have 1 to 4 carbon atoms, an alkylideneimino group, wherein the alkylidene group has 1 to 4 carbon atoms, a benzylideneimino group or an acylamino group, and pharmaceutically acceptable acid addition salts thereof. The novel compounds of the general formula I can be employed primarily as analgesic agents.
A pyrazolo quinazoline of the formula ##STR14## wherein R represents a hydrogen atom, a C.sub.1-4 alkyl group or a C.sub.1-4 alkanoyl group,
A nitropyrazolo[1,5-c]quinazoline of the formula ##STR15## wherein R.sub.2 represents a hydrogen atom or a C.sub.1-4 alkyl group, and pharmaceutically acceptable acid addition salts thereof.
An aminopyrazolo[1,5-c]quinazoline of the formula ##STR16## wherein R.sub.2 represents a hydrogen atom or a C.sub.1-4 alkyl group,
A nitropyrazolo[1,5-c]quinazoline of the formula ##STR17## wherein R.sub.1 and R.sub.2 represent hydrogen, and pharmaceutically acceptable acid addition salts thereof.
A nitropyrazolo[1,5-c]quinazoline of the formula ##STR18## wherein R.sub.1 represents a C.sub.1-4 alkyl group,
An aminopyrazolo[1,5-c]quinazoline of the formula ##STR19## wherein R represents a hydrogen atom or a C.sub.1-4 alkanoyl group,
1-Nitropyrazolo[1,5-c]quinazoline.
1-Nitro-5-methylpyrazolo[1,5-c]quinazoline.
1-Acetaminopyrazolo[1,5-c]quinazoline.
1-Nitro-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline.
1-Nitro-5,5-dimethyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline.
1-Acetamino-5,5-dimethyl-5,6-dihydropyrazolo[1,5-c]quinazoline.
1-Acetamino-5,5-dimethyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]qui nazoline.
1-Acetamino-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline.
1-Acetamino-5-methylpyrazolo[1,5-c]quinazoline.
Dependencies are inferred from the claim text.