3,7-Disubstituted-3-cephem-4-carboxylic acid compounds
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsTakashi Kamiya, Kunihiko Tanaka, Yoshiharu Nakai, Kazuo Sakane
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Abstract
Antibiotic cephalosporin compounds, method of making and pharmaceutical composition thereof represented by the general formula ##STR1## wherein R.sup.1 is amino, lower alkylamino, a protected amino, a protected lower alkylamino, hydroxy or lower alkoxy, R.sup.2 is hydrogen, acyloxy, pyridium or a heterocyclicthio group which may have suitable substituent(s), R.sup.3 is carboxy or its derivative, A is carbonyl, hydroxy(lower)alkylene or a protected hydroxy(lower)alkylene and R.sup.4 is hydrogen or halogen, or R.sup.2 and R.sup.3 are linked together to represent a group of the formula --COO--.
Claims12
The compound of the formula:
- ##STR12## wherein R.sup.1 is amino, (C.sub.1 to C.sub.6)alkylamino, an amino group protected by an eliminatable protective acyl group or hydroxy, and
- R.sup.2 is triazolylthio, tetrazolylthio, thiadiazolylthio or oxadiazolylthio wherein each of which may have a (C.sub.1 to C.sub.6)alkyl, and
- pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.