Heparin fragments having selective anticoagulation activity
AssigneeAB Kabi
InventorsUlf P. F. Lindahl, Gudrun E. Backstrom, John Y. L. Thunberg, Lars-Ake Fransson, Lars-Olov Andersson, Erik Y. Holmer, Inga H. Sandberg, Ewa G. Soderstrom
Life of this patent
Estimating the term…
Abstract
Heparin fragments having selective anticoagulation activity having 14-18 sugar units, the disaccharide unit L-iduronosyl-2-O-sulphate-N-sulpho-U-glucosamine-6-O-sulphate being the main component, and where unsulphated L-iduronic acid is in a position situated 3-5 sugar units from the unreducing terminal. Pharmaceutical compositions containing such heparin fragments. Processes for the preparation of the heparin fragments.
Claims6
Heparin fragments having 14-18 sugar units, wherein the main component is the disaccharide unit L-iduronosyl-2-O-sulphate-N-sulpho-D-glucosamine-6-O-sulphate, and where unsulphated L-iduronic acid is in a position situated 3-5 sugar units from the unreducing terminal and is followed by a unit selected from the group consisting of N-sulpho-D-glucosamine sulphate and N-acetyl-glucosamine in sulphated and unsulphated form.
Heparin fragments having the structure (U-G).sub.n -I-G-(U-G).sub.m where n is 1 or 2 and m is 5 or 6, I is unsulphated L-iduronic acid, U is L-iduronic acid-2-O-sulphate, and G is N-sulpho-D-glucosamine-6-O-sulphate.
Pharmaceutical compositions for preventative treatment or treatment of arterial thrombosis containing heparin fragments having selective anticoagulation activity and containing 14-18 sugar units, wherein the main component is the disaccharide unit L-iduronosyl-2-O-sulphate-N-sulpho-D-glucosamine-6-O-sulphate, and where unsulphated L-iduronic acid is in a position situated 3-5 sugar units from the unreducing terminal and is followed by a unit selected from the group consisting of N-sulpho-D-glucosamine sulphate and N-acetyl-glucosamine in sulphated and unsulphated form in an amount sufficient for anticoagulation activity;
- and a pharmaceutical carrier.
Pharmaceutical composition for preventative treatment or treatment of arterial thrombosis containing heparin fragments of the structure (U-G).sub.n -I-G-(U-G).sub.m where n is 1 or 2 and m is 5 or 6, I is unsulphated L-iduronic acid, U is L-iduronic acid-2-O-sulphate and G is N-sulpho-D-glucosamine-6-O-sulphate in an amount sufficient for anticoagulation activity;
- and a pharmaceutical carrier.
Dependencies are inferred from the claim text.