Farnesylacetic acid amides
AssigneeKuraray Co., Ltd.
InventorsSusumu Okabe, Yoshiaki Omura, Yoichi Ninagawa, Yoshiji Fujita
Life of this patent
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Abstract
Novel farnesylacetic acid amide compounds represented by general formula ##STR1## wherein A is alkylene of at least 2 carbon atoms, R.sup.1 is H or lower alkyl, and R.sup.2 and R.sup.3 are each independently H, alkyl, cycloalkyl, alkenyl, aryl or aralkyl, or either one of R.sup.2 and R.sup.3 is such a group that forms, together with A, a piperidine or pyrrolidine ring which contains as constituent thereof the nitrogen atom lying therebetween, or R.sup.2 and R.sup.3 combinedly represent a group which forms, together with the nitrogen atom to which they are bonded, a piperidine, pyrrolidine or piperazine ring; and salts thereof have antiulcerogenic and antibacterial activities.
Claims10
A farnesylacetic acid amide compound of the formula ##STR30## wherein A is a straight or branched alkylene group having from 2 to 10 carbon atoms,
- R.sup.1 is a hydrogen atom or a lower alkyl group, and
- R.sup.2 and R.sup.3 are the same or different and each is a hydrogen atom, C.sub.1 -C.sub.10 alkyl, C.sub.5 or C.sub.6 cycloalkyl, methylcyclohexyl, C.sub.2 -C.sub.15 alkenyl, phenyl, tolyl, xylyl, benzyl or phenethyl,
- or either of R.sup.2 and R.sup.3 forms, together with A, a piperidine or pyrrolidine ring which contains the nitrogen atom lying therebetween,
- or R.sup.2 and R.sup.3 form, together with the adjacent nitrogen atom a piperidine, pyrrolidine piperazine or N-methylpiperazine ring;
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.