Spray drying process for preparation of solid sodium amoxycillin
AssigneeBeecham Group Limited
InventorsDavid H. S. Shean, John R. Steel
Life of this patent
Estimating the term…
Abstract
Sodium amoxycillin is obtained by spray drying a solution of sodium amoxycillin in aqueous isopropyl alcohol, wherein the initial ratio of isopropyl alcohol to sodium amoxycillin present in the solution to be spray dried is from 5:3 to 3:1 w/w.
Claims3
A process for the preparation of solid sodium amoxycillin of improved stability and purity which comprises subjecting a solution consisting of from 5% to 25% by weight sodium amoxycillin in aqueous isopropanol wherein the initial weight ratio in the solution of isopropanol to sodium amoxycillin, which solution has been cooled to from 5.degree. to -10.degree. C., to spray drying at an inlet temperature of from 155.degree. to 200.degree. C. and an outlet temperature of from 95.degree. to 110.degree. C., with a retention time of from 1 to 2 seconds.
Dependencies are inferred from the claim text.