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US 4,302,599 AGranted
Process for nitrating anilides
AssigneeSchering Corporation
InventorsLydia Peer, Joseph Mayer
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Abstract
This invention describes a novel process whereby meta-substituted anilides are nitrated in the para position in high yields.
Claims11
The process for para nitrating a meta-substituted anilide wherein the meta-substituent is selected from the group consisting of lower alkyl, lower acyl, polyfluoro lower alkyl, nitrogen and halogen;
- which comprises subjecting said meta-substituted anilide to a mixed acid solution consisting of nitric acid and oleum wherein the reaction temperature is maintained at from about -20.degree. C. to about 50.degree. C., the nitric acid is present at from about 1 to about 4.5 moles per mole of anilide and the oleum is present at from about 1.5 to about 10 milliliters per gram of anilide.
Dependencies are inferred from the claim text.