Intermediates for the preparation of 4-aryloxy-3-phenylpiperidines
AssigneeHoechst-Roussel Pharmaceuticals Inc.
InventorsSolomon S. Klioze, Frederick J. Ehrgott
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Abstract
Novel 4-aryloxy- and 4-arylthio-3-phenylpiperidines and related compounds, physiologically acceptable salts thereof and intermediates therefor possessing analgesic, antidepressant properties, and a process for the preparation of such compounds, derivatives and intermediates are described.
Claims7
A compound of the formula ##STR20## or a salt thereof in which R is hydrogen, methyl, lower alkanoyl, cycloloweralkylloweralkanoyl, cycloloweralkylloweralkyl, loweralkenyl, loweralkynyl, ##STR21## wherein R.sub.1 is loweralkyl, loweralkenyl or CH.sub.2 CCl.sub.3, or ##STR22## where Z is hydrogen, halogen, loweralkyl, loweralkoxy, hydroxy, nitro or amino and R.sub.2 is loweralkylene, oxyloweralkylene, loweralkylenecarbonyl, carbonylloweralkylene or ##STR23## wherein n is 1, 2 or 3 and Y is hydrogen, loweralkyl, halogen, hydroxy, nitro, amino, acetamido, trifluoromethyl or cyano.
A compound which is cis- or trans-1-methyl-3-phenyl-4-piperidinol.
Dependencies are inferred from the claim text.