Cis-mono and disubstituted-2-methyl-3-[(piperazinyl) and (piperidino)ethyl]indolines, intermediates for their preparation and methods of preparation
AssigneeAmerican Cyanamid Company
InventorsWilliam J. Fanshawe, Thomas C. McKenzie, Lantz S. Crawley
Life of this patent
Estimating the term…
Abstract
Novel substituted 3-[2-(4-phenyl or pyridyl-1-piperazinyl or piperidino)ethyl]indolines useful as antipsychotic agents in mammals as well as substituted 3-[2-(4-phenylpiperidino)ethyl]indole intermediates for their preparation.
Claims5
The compound cis-5-fluoro-2-methyl-3-[2-(4-phenylpiperidino)ethyl]indoline dihydrochloride.
The compound cis-5,-6-dimethoxy-2-methyl-3-[2-(4-phenylpiperidino)ethyl]indoline dihydrochloride.
A compound selected from those of the formula:
- ##STR4## wherein R'.sub.1 is selected from the group comprising fluorine and methoxy and R'.sub.2 is hydrogen and methoxy, and the pharmacentically acceptable salts thereof.
The compound in accordance with claim 3, 5-fluoro-2-methyl-3-[2-(4-phenylpiperidino)ethyl]indole.
The compound in accordance with claim 3, 5,6-dimethoxy-2-methyl-2-[2-(4-phenylpiperidino)ethyl]indole hydrochloride.
Dependencies are inferred from the claim text.