4(or 3)-(3,4-Dihydroxyphenyl)pyridines, their cardiotonic use and cardiotonic use of their methyl ethers
AssigneeSterling Drug Inc.
InventorsJoseph C. Collins, George Y. Lesher, Baldev Singh
Life of this patent
Estimating the term…
Abstract
4(or 3)-(3,4-Dihydroxyphenyl)pyridine, a cardiotonic agent, is prepared by demethylating 4(or 3)-(3,4-dimethoxyphenyl)pyridine, preferably by heating with aqueous hydrogen bromide. 4(or3)-[3,4-di-(OR)-phenyl]pyridine, where R is hydrogen or methyl, or pharmaceutically-acceptable acid-addition salt thereof is disclosed as the active component in a cardiotonic composition for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment. The novel isomeric 2-[3,4-di-(OR)-phenyl]pyridine, where R is hydrogen or methyl, is shown for comparative purposes.
Claims5
4(or 3)-(3,4-Dihydroxyphenyl)pyridine or pharmaceutically-acceptable acid-addition salt thereof.
4-(3,4-Dihydroxyphenyl)pyridine or pharmaceutically-acceptable salt thereof.
A cardiotonic composition for increasing cardiac contractility, said composition comprising a pharmaceutically-acceptable inert carrier and, as the active component thereof, an effective amount of the cardiotonic 4(or 3)-[3,4-di-(OR)-phenyl]pyridine or pharmaceutically-acceptable acid-addition salt thereof, where R is hydrogen or methyl.
The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering orally or parenterally in a solid or liquid dosage form to such patient an effective amount of the cardiotonic 4(or 3)-[3,4-di-(OR)-phenyl]pyridine or pharmaceutically-acceptable acid-addition salt thereof, where R is hydrogen or methyl.
Dependencies are inferred from the claim text.