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US 4,302,461 AGranted
Antiinflammatory 5-substituted-2,3-diarylthiophenes
AssigneeE. I. Du Pont de Nemours and Company
InventorSaul C. Cherkofsky
Life of this patent
Estimating the term…
Abstract
Antiinflammatory 5-substituted-2,3-diarylthiophenes, such as 2,3-bis(4-fluorophenyl)-5-(trifluoromethylthio)thiophene, useful for treating arthritis and related diseases.
Claims36
A compound of the formula:
- ##STR14## where R.sup.1 =mono- or polyfluoro C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkyl;
- n=0, 1 or 2;
- R.sup.3 and R.sup.4 independently=pyridyl or ##STR15## X=H, F, Cl, Br, NO.sub.2, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, di(C.sub.1 -C.sub.2 alkyl)amino, or S(O).sub.m R.sup.2 ;
- where
- m=0, 1 or 2;
- and
- R.sup.2 =CH.sub.3 or C.sub.2 H.sub.5 ;
- Y=H, F or Cl with the proviso that when Y is F or Cl, then X is F or Cl;
- R.sup.5 =H, C.sub.1 -C.sub.4 alkyl or allyl;
- provided
- (a) when R.sup.1 =C.sub.1 -C.sub.6 alkyl, R.sup.3 and R.sup.4 cannot both be phenyl;
- or
- (b) when n=2, R.sup.3 and R.sup.4 cannot both be phenyl.
10 more elements
Dependencies are inferred from the claim text.