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US 4,302,459 AGranted
Liposome carriers in leishmaniasis chemotherapy with 8-aminoquinoline derivatives
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsEdgar A. Steck, Carl R. Alving
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Abstract
An improved method is provided for the chemotherapy of leishmanial infects. An 8-aminoquinoline anti-leishmanial agent is encapsulated within liposomes and the liposome-encapsulated drug is injected into the body. Subject use of a liposome carrier has produced marked enhancement of the effectiveness of the drug against leishmanial parasites in the liver (such as characteristic of infections which are difficult to treat).
Claims17
The product prepared by a process for encapsulating an anti-leishmanial 8-aminoquinoline drug within liposomes comprising the steps of:
- a. drying a lipid mixture to form a dry film;
- b. wetting the lipid film with an aqueous solution of an 8-aminoquinoline drug;
- c. mixing the aqueous solution of an 8-aminoquinoline drug and lipid film to form a suspension of an 8-aminoquinoline drug encapsulated by liposomes;
- d. separating the liposome-encapsulated drug;
- and
- e. washing the liposome-encapsulated 8-aminoquinoline drug to remove substantially all nonencapsulated 8-aminoquinoline drug therefrom.
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Dependencies are inferred from the claim text.