Phthalidyl-isoquinoline derivatives
AssigneesLaborec Laboratoire de Recherches Biologiques, Calaire Chimie, S.A.
InventorsJacques A. Chazerain, Hubert Y. Cotereau, Pierre H. Lallouette, Hugues A. Legger, Pierre A. C. Lepape
Life of this patent
Estimating the term…
Abstract
The phthalidyl-isoquinoline derivatives have the formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.4, R.sub.5 and R.sub.6 each denotes a lower alkoxy group, R.sub.3 denotes a hydrogen atom or a lower alkoxy group and R.sub.7 denotes a lower alkyl group and also include their diastereoisomers and their addition salts with pharmaceutically acceptable acids. These compounds have antiallergic activities and may be used to treat allergic symptoms in human beings and other animals.
Claims9
A compound of the formula ##STR6## wherein each of R.sub.1, R.sub.2, R.sub.4, R.sub.5 and R.sub.6 is lower alkoxy;
- R.sub.3 is hydrogen or lower alkoxy;
- and
- R.sub.7 is lower alkyl
- or a diasterioisomer thereof or a pharmaceutically acceptable acid addition salt thereof.
2-methyl-6, 7-dimethoxy-1-[4,5,6-triethoxy-7-amino-3-phthalidyl]-1,2,3,4-tetrahydro-iso quinoline.
2-methyl-6,7,8-trimethoxy-1-[4,5,6-triethoxy-7-am ino-3-phthalidyl]-1,2,3,4-tetrahydro-isoquinoline.
A pharmaceutical composition for inhibiting an allergic condition in a patient which comprises a compound of claim, 2, 1, 3 or 4 and a physiologically acceptable carrier or diluent.
A pharmaceutical composition in dosage unit form for the treatment of allergies which comprises an effective amount of 2-methyl-6,7,8-trimethoxy-1-[4,5,6-triethoxy-7-amino-3-phthalidyl]-1,2,3,4 -tetrahydro-isoquinoline and a pharmaceutically acceptable carrier or diluent therefor.
Dependencies are inferred from the claim text.