Process for therapeutic treatment
AssigneesThe Upjohn Company, The Regents of the University of Michigan
InventorsJohn J. Voorhees, Wendell Wierenga
Life of this patent
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Abstract
This invention relates to a new method of therapy comprising the administration of a pro-drug to a human or animal, said pro-drug being a compound formed by a therapeutic compound chemically combined with another moiety by a photocleavable bond and irradiating the diseased area with ultraviolet radiation in an amount sufficient to cleave the bond and release the therapeutic compound in a therapeutically effective amount. Specifically disclosed are pro-drugs which are cleaved to therapeutically active medications which are anti-proliferative and anti-inflammatory compounds and the treatment of inflammatory and/or proliferative skin diseases therewith.
Claims1
A process for treating a dermatological disease which comprises:
- (a) administering to a human or animal afflicted with a dermatological disease a composition comprising a pro-drug in combination with a pharmaceutical carrier, and
- (b) irradiating the diseased area with radiation having a wave length of from about 2500 to about 3600 angstroms in an amount sufficient to convert said administered pro-drug to a pharmaceutically active form and in a concentration effective to alleviate the said disease and the pro-drug is a compound of the formula:
- ##STR140## wherein R.sub.1 and R.sub.2 are selected from the group H and ##STR141## X is H, methoxy, chloro and bromo, provided that one of the groups R.sub.1 and R.sub.2 is not H.
Dependencies are inferred from the claim text.