Antiarrhythmic tetrahydronaphthalene derivatives
AssigneeE. R. Squibb & Sons, Inc.
InventorsFrederic P. Hauck, Rita T. Fox
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Abstract
Compounds are provided having the structure ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are hydrogen, lower alkyl, lower alkenyl, or hydroxy-lower alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached also form a heterocyclic radical which may contain another heteroatom, namely nitrogen, oxygen or sulfur; R.sup.3 and R.sup.4 may be the same or different and are hydrogen or lower alkyl. These compounds are useful in the treatment or arrhythmia. In addition, novel intermediates are provided having the structure ##STR2## wherein R is hydrogen, benzyl or ##STR3## These intermediates are also useful in treating acute myocardial infarction.
Claims13
A compound having the formula ##STR48## wherein R.sup.1 and R.sup.2 are the same or different and are hydrogen, lower alkyl, lower alkenyl or hydroxy-lower alkyl, or R.sup.1 and R.sup.2 are taken together with the nitrogen atom to which they are attached to form a 5- to 7-membered heterocyclic ring containing one or two heteroatoms, and which may contain in addition to said nitrogen atom, one nitrogen, oxygen or sulfur atom;
- R.sup.3 and R.sup.4 are the same or different and are hydrogen or lower alkyl, and physiologically acceptable acid-addition salts thereof, and stereoisomers thereof.
Dependencies are inferred from the claim text.