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US 4,302,398 AGranted
Cyclic compounds
AssigneeHoffmann-La Roche Inc.
InventorsCedric H. Hassall, Michael J. Broadhurst, Gareth J. Thomas
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AssigneeHoffmann-La Roche Inc.
InventorsCedric H. Hassall, Michael J. Broadhurst, Gareth J. Thomas
Estimating the term…
The present invention relates to naphthacene derivatives. More particularly, the invention is concerned with a process for the manufacture of hexahydronaphthacene derivatives and with certain of said derivatives per se. The invention is also concerned with novel intermediates occurring in said process and with the preparation thereof. There are presented hexahydronaphthacene derivatives of the formula ##STR1## wherein R.sup.1 represents a lower alkyl or esterified carboxy group or a group of the formula ##STR2## , in which R.sup.2 and R.sup.3 together form an oxo group or a protected oxo group and X represents a hydrogen atom or a hydroxy or acyloxy group, or --(CH.sub.2).sub.n --OY b in which n stands for 1 or 2 and Y represents a hydrogen atom or an alkyl or acyl group. Also presented are intermediates and a process to produce the compounds of formula I.
A process for the manufacture of compounds of the formula ##STR23## wherein R.sup.1 is selected from the group consisting of an esterified carboxy group and a group of the formula ##STR24## in which R.sup.2 and R.sup.3 together are an oxo group or a ketal or thioketal group and X is selected from the group consisting of a hydrogen atom, a hydroxy group, an acyloxy group, and
A compound of the formula ##STR30## wherein R.sup.1 is selected from the group consisting of lower alkyl, an esterified carboxy group and a group of the formula ##STR31## in which R.sup.2 and R.sup.3 together are an oxo group or a ketal or thioketal group and X is selected from the group consisting of a hydrogen atom, a hydroxy group, an acyloxy group, and
A compound of the formula ##STR32## wherein R.sup.1 is selected from the group consisting of an esterified carboxy group and a group of the formula ##STR33## in which R.sup.2 and R.sup.3 together are an oxo group or a ketal or thioketal group and X is selected from the group consisting of a hydrogen atom, a hydroxy group, an acyloxy group, and
A compound of the formula ##STR34## wherein R.sup.1 is selected from the group consisting of lower alkyl, an esterified carboxy group and a group of the formula ##STR35## in which R.sup.2 and R.sup.3 together are an oxo group or a ketal or thioketal group and X is selected from the group consisting of a hydrogen atom, a hydroxy group, an acyloxy group, and
Dependencies are inferred from the claim text.