Antigenic modification of polypeptides
AssigneeThe Ohio State University
InventorVernon C. Stevens
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Abstract
Modified hormones or fragments of hormones are useful in producing antibodies when administered to an animal. Said antibodies in turn cause neutralization of endogenous natural protein hormones. The modification may be accomplished by attaching various kinds of modifying groups to the hormone or fragment. Modification may, for example, be achieved by chemically coupling diazosulfanilic acid groups to the hormone or fragment. The protein hormones to which this procedure can be applied are mammalian protein reproductive hormones such as, for example, Follicle Stimulating Hormone (FSH), or Human Chorionic Gonadotropin (HGG). These modified hormone or fragment may be administered to animals for the purpose of contraception, abortion, or treatment of hormone related disease states and disorders.
Claims35
A modified polypeptide for isoimmuniogically controlling biological action in a mammal by antibody formation, consisting of a protein hormone, a non-hormonal protein, or a fragment of either which has been chemically modified outside the body of said mammal, said protein hormone, non-hormonal protein or fragment having the properties of:
- (a) in unmodified form, being non-immunogenic to said mammal and having a moleculr structure similar to an endogenous protein hormone or a non-hormonal protein, the biological function of which it is desired to inhibit, or fragment of either and
- (b) in modified form, causing antibodies to be formed in the body of the mammal which inhibit the biological function of said endogenous protein hormone or non-hormonal protein following administration of the modified form into the body of said mammal.
Dependencies are inferred from the claim text.