4-Phenoxy-phenoxy-alkane-carboxylic acid derivatives and process for their manufacture
AssigneeHoechst Aktiengesellschaft
InventorsHelmut Nahm, Ernold Granzer
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AssigneeHoechst Aktiengesellschaft
InventorsHelmut Nahm, Ernold Granzer
Estimating the term…
Novel 4-phenoxy-phenoxy-alkane-carboxylic acid derivatives of the formula I ##STR1## in which R.sub.1 stands for hydrogen, methylthio, cyclopentyl, cyclohexyl, phenyl, methylcyclohexyl, ethylcyclohexyl, or R.sub.1 and R.sub.3 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge or--unless at least one of the substituents R.sub.2 to R.sub.8 stands for hydrogen, or if R.sub.9 stands for a radical having at least 2 carbon atoms--for chlorine, R.sub.2 and R.sub.3, independent of one another, each stands for hydrogen, chlorine or alkyl of 1 to 4 carbon atoms, R.sub.4 stands for hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, methylcyclohexyl or R.sub.3 and R.sub.4 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge, R.sub.5, R.sub.6 and R.sub.7, independent of one another, each stands for hydrogen or alkyl of 1 to 4 carbon atoms, R.sub.8 stands for hydrogen, alkyl of 1 to 4 carbon atoms or allyl, R.sub.9 stands for alkyl of 1 to 10 carbon atoms or phenyl and X stands for hydrogen, the cation of a physiologically acceptable inorganic or organic base of a hydrocarbon radical of 1 to 10 carbon atoms, having a strong action on the lipide and cholesterine metabolism and a process for their manufacture.
An ester of the formula ##STR24## X is alkyl having 1 to 4 carbon atoms.
An ester derived from (a) a 4-phenoxy-phenoxy alkane carboxylic acid of the formula ##STR25## an alcohol having 1 to 4 carbon atoms.
An ester of the formula ##STR26## where R is a hydrocarbon radical having 1 to 10 carbon atoms, derived from (a) a 4-phenoxy-phenol of the formula ##STR27## an .alpha.-halogeno fatty acid compound of the formula ##STR28## wherein Y is bromine or chlorine, and X is hydrogen, an organic or inorganic cation, or R, but if X is other than R then the compound formed esterified with a hydrocarbon alcohol having 1 to 10 carbon atoms to form the desired ester.
Dependencies are inferred from the claim text.