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US 4,301,294 AGranted
16-Phenoxy PGE.sub.2 compounds
AssigneeThe Upjohn Company
InventorNorman A. Nelson
Life of this patent
Estimating the term…
Abstract
Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
Claims8
An optically active compound of the formula ##STR1## or a racemic compound of that formula and the mirror immage thereof, wherein g is an integer from 2 to 5, inclusive;
- wherein M is .alpha.-OH:.beta.-H or .beta.-OH:.alpha.-H;
- wherein R.sub.1 is hydrogen or alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive;
- wherein R.sub.2 and R.sub.3 are hydrogen, methyl, or ethyl;
- wherein T is alkyl of one to 3 carbon atoms, inclusive, fluoro, chloro, trifluoromethyl, or --OR.sub.4, wherein R.sub.4 is alkyl of one to 3 carbon atoms, inclusive, and
- wherein s is zero, one, 2, or 3, with the proviso that not more than two T's are other than alkyl, including the lower alkanoates thereof, and the pharmacologically acceptable salts thereof when R.sub.1 is hydrogen.
2 more elements
Dependencies are inferred from the claim text.