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US 4,301,285 AGranted
Sydnonimine CNS stimulants
AssigneeAmerican Home Products Corporation
InventorReinhardt P. Stein
Life of this patent
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Abstract
This application provides a novel process for the synthesis of 3-[1(hydroxymethyl)-2-phenylethyl]-N-[(phenylamino)carbonyl]sydnonimine derivatives and novel hydrophobic and hydrophilic acyl derivatives thereof as pro-drug central nervous system stimulants.
Claims9
A hydroxyl protected 3-[1-(hydroxymethyl)-2-phenylethyl)]-N-[(phenylamino)carbonyl]sydnone imine derivative of the formula:
- ##STR11## in which R.sup.1 and R.sup.2 are, independently, hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halo, perfluoroalkyl of 1 to 3 carbon atoms, nitro, alkanoyl of 2 to 4 carbon atoms, or alkoxycarbonyl of 2 to 4 carbon atoms;
- R.sup.3 is hydrogen, halo, nitro or alkanoyl of 2 to 4 carbon atoms;
- R.sup.4 is hydrogen, halo, nitro or perfluoroalkyl of 1 to 3 carbon atoms;
- R.sup.5 and R.sup.6 are, independently, hydrogen, methyl or ethyl and
- B is a hydroxy protecting group.
2 more elements
Dependencies are inferred from the claim text.