3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
AssigneeSRI International
InventorsEdward M. Acton, Carol W. Mosher
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Abstract
Described are 3'-deamino-3'-(4-morpholinyl) derivatives of daunorubicin and doxorubicin having the formula ##STR1## wherein R is COCH.sub.3 or --CHOHCH.sub.3 in the case of daunorubicin derivatives, or is --COCH.sub.2 OH or --CHOHCH.sub.2 OH in the case of doxorubicin derivatives together with their pharmaceutically acceptable acid addition salts. The compounds have utility as antitumor agents.
Claims7
Compounds of the formula ##STR3## wherein R is selected from the group consisting of --COCH.sub.3, --CHOHCH.sub.3, --COCH.sub.2 OH and --CHOHCH.sub.2 OH and the pharmaceutically acceptable acid addition salts of said compounds.
Dependencies are inferred from the claim text.