E-Type prostaglandin compositions
AssigneeThe Upjohn Company
InventorSamuel H. Yalkowsky
Life of this patent
Estimating the term…
Abstract
PGE-type compounds are stabilized in a composition comprising a mixture of triacetin and ethanol. This composition surprisingly and unexpectedly retains virtually all of the stability of triacetin compounds and additionally provides the superior water miscibility of ethanol.
Claims16
A stable, rapidly water miscible composition comprising (a) an amount of a stabilizing rapidly water miscible vehicle consisting essentially of ethanol and triacetin in a volume to volume ratio from about 1:3 to about 3:1;
- and
- (b) a quantity of an E-type prostaglandin which when dissolved in said amount of said vehicle is present therein in a concentration of greater than zero and less than about 100 mg/ml.
A stable, rapidly water miscible pharmaceutical composition comprising
- (a) a dose of an E-type prostaglandin;
- (b) a quantity of a stabilizing rapidly water miscible vehicle consisting essentially of ethanol and triacetin in a volume to volume ratio from about 1:3 to about 3:1 such that said dose of said E-type prostaglandin is dissolved in said vehicle at a concentration greater than zero and less than about 100 mg/ml.
In a stable pharmaceutical composition comprising an E-type prostaglandin and triacetin, the improvement which comprises ethanol in an amount of about one to about 3 parts by volume per part by volume of triacetin, whereby there is obtained a stable and rapidly water miscible E-type prostaglandin composition.
In a rapidly water miscible pharmaceutical composition comprising an E-type prostaglandin and ethanol, the improvement which comprises:
- triacetin in an amount of about one to about 3 parts by volume per part by volume of ethanol, whereby there is obtained a stable and rapidly water miscible E-type prostaglandin composition.
Dependencies are inferred from the claim text.