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AssigneeEisai Co., Ltd.
InventorsMotosuke Yamanaka, Isao Saito, Kiyomi Yamatsu, Takako Fujimoto
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An imidazole compound of the formula: ##STR1## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, lower alkyl, trifluoromethyl, amino, mono- or di-lower alkylamino, heterocyclic amino, halogen or ##STR2## (in which R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, A is carbonyl or sulfonyl, and R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, unsubstituted phenyl or phenyl having halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino or phenylamino having halogen, lower alkyl, lower alkoxy or trifluoromethyl); and their pharmaceutically acceptable acid addition salts.
A method for treating depression which comprises administering to a patient suffering from depression a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR275## in which R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, A is carbonyl or sulfonyl, R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, or phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, and pharmaceutically acceptable acid addition salts thereof, and a pharmaceutical carrier.
A method for treating depression which comprises administering to a patient suffering from depression a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR276## in which R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, R.sub.7 is lower alkyl, halogenated lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylaminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, or phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, and pharmaceutically acceptable acid addition salts thereof, and a pharmaceutical carrier.
A method for treating depression which comprises administering to a patient suffering from depression a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula ##STR277## in which R.sub.1 is lower alkyl, R.sub.2 is hydrogen or lower alkyl, R.sub.6 is hydrogen, lower alkyl or lower alkylsulfonyl, R.sub.7 is lower alkyl, halogenated lower alkyl, mono- of di-lower alkylamino, mono- or di-lower alkylaminoalkyl, phenyl, phenyl substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, phenylamino, or phenylamino substituted with halogen, lower alkyl, lower alkoxy or trifluoromethyl, and pharmaceutically acceptable acid addition salts thereof, and a pharmaceutical carrier.
Dependencies are inferred from the claim text.