2-Amino thiazoline derivatives
AssigneeInstitut Merieux
InventorsAndre L. Boucherle, Marie-Pierre D. Viallet
Life of this patent
Estimating the term…
Abstract
2-amino thiazoline derivative having Formula I: ##STR1## wherein: R represents --R.sub.1 or --CO--R.sub.2, wherein R.sub.1 represents benzyl monosubstituted in the ortho position by lower alkoxy or in the ortho, meta or para position by lower alkyl, trifluoromethyl or halogen, or R.sub.1 represents cycloalkylmethyl; and R.sub.2 represents cycloalkyl, naphthyl, styryl or substituted phenyl; and R.sub.3, R.sub.4, R.sub.5 and R.sub.6, each independently represent hydrogen or lower alkyl. The said 2-amino thiazoline is useful as a medicine in the preparation of pharmaceutical compositions.
Claims13
2-amino thiazoline derivative having the Formula I:
- ##STR7## wherein:
- R represents --R.sub.1 or --CO--R.sub.2, wherein R.sub.1 represents benzyl monosubstituted in the ortho position by lower alkoxy or in the ortho, meta or para position by lower alkyl, trifluoromethyl or halogen, or R.sub.1 represents cycloalkylmethyl wherein the cycloalkyl moiety has 5 or 6 chains;
- and R.sub.2 represents cycloalkyl, naphthyl, styryl or substituted phenyl, the phenyl moiety being monosubstituted or disubstituted by halogen, lower alkyl, lower alkoxy, trifluoromethyl or nitro;
- and R.sub.3, R.sub.4, R.sub.5 and R.sub.6, each independently represent hydrogen or lower alkyl group.
A derivative selected from the group consisting of (p-chlorobenzyl) 2-amino thiazoline;
- (p-methylbenzyl) 2-amino-2 thiazoline;
- (p-bromobenzyl) 2-amino thiazoline;
- (o-methylbenzyl) 2-amino thiazoline;
- (m-trifluoromethylbenzyl) 2-amino thiazoline;
- (o-chlorobenzyl) 2-amino thiazoline;
- (cyclohexylmethyl) 2-amino thiazoline;
- (.alpha.-naphthylmethyl) 2-amino thiazoline;
- (o-methoxybenzyl) 2-amino thiazoline and the addition salts thereof.
(o-toluoyl) 2-amino thiazoline.
Dependencies are inferred from the claim text.