5,6,7-Trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives
AssigneeToray Industries, Inc.
InventorsKiyotaka Ohno, Hisao Nishiyama, Shintaro Nishio
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Abstract
Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-16,17,18,19,20-pentanor-15-phenyl PGI.sub.2.
Claims33
A compound of the formula ##STR63## wherein R.sub.1 is (a) carboxyl group, (b) its salt, (c) its ester, (d) its amide or (e) --CH.sub.2 OH, n is an integer of from 1 to 3, W is ##STR64## wherein R.sub.8 is hydrogen, acyl of 1 to 12 carbon atoms, tetrahydropyranyl, tetrahydrofuranyl or 1-ethoxyethyl, X is ##STR65## R.sub.9 is (a) hydrogen or (b) alkyl of 1 to 4 carbon atoms, R.sub.10 is (a) straight alkyl of 4 to 12 carbon atoms, ##STR66## wherein Z is a valence bond or alkylene of 1 to 5 carbon atoms, m is an integer of from 5 to 12, R.sub.3 is hydrogen or alkyl of 1 to 5 carbon atoms, or (c) --Z--Ar.sub.2 wherein Z is as defined above, Ar.sub.2 is phenyl, .alpha.-naphthyl, .beta.-naphthyl or phenyl substituted by at least one chloro, bromo, fluoro, trifluoromethyl, alkyl of 1 to 4 carbon atoms, nitro, methoxy, phenyl or phenoxy.
5,6,7-trinor-4,8-inter-m-phenylene-16,17,18,19,20-pentanor-15-phenyl PGI.sub.2.
5,6,7-t rinor-4,8-inter-m-phenylene-16,17,18,19,20-pentanor-15-cyclohexyl PGI.sub.2
5,6,7-trinor-4,8-inter-m-phenylene-16,17,18,19,20-pentanor-15-cyclopent yl PGI.sub.2.
5,6,7-trinor-4,8-inter-m-phenylene-17,18,19,20-tetranor-16-cyclohexyl PGI.sub.2.
5,6,7-trinor-4,8-inter-m-phenylene-17,18,19,20-tetranor-16-phenyl PGI.sub.2.
5,6,7-trinor-4,8-inter-m-phenylene-17,18,19,20-tetranor-16-p-tolyl PGI.sub.2.
5,6,7-t rinor-4,8-inter-m-phenylene-13,14-dihydro-16,17,18,19,20-pentanor-15-phenyl PGI.sub.2.
5,6,7-t rinor-4,8-inter-m-phenylene-13,14-dihydro-16,17,18,19,20-pentanor-15-cycloh exyl PGI.sub.2.
5,6,7-trino r-4,8-inter-m-phenylene-13,14-dihydro-16,17,18,19,20-pentanor-15-cyclopenty l PGI.sub.2.
11-acety l-5,6,7-trinor-4,8-inter-m-phenylene-16,17,18,19,20-pentanor-15-(p-tolyl) PGI.sub.2 benzyl ester.
5,6,7-trinor-4,8-inter-m-phenylene-16,17,18,19,20-pentanor-15-(p-tolyl) PGI.sub.2.
5,6,7-t rinor-4,8-inter-m-phenylene-16,17,18,19,20-pentanor-15-cyclohexyl PGI.sub.2 methyl ester.
5,6,7-trinor-4,8-inter-m-phenylene-16,17,18,19,20-pentanor-15-phenyl PGI.sub.2 ethyl ester.
5,6,7-trinor-4,8-inter-m-phenylene-17,18,19,20-tetranor-16-cyclohexyl PGI.sub.2 methyl ester.
5,6,7-trinor-4,8-inter-m-phenylene-17,18,19,20-tetranor-16-phenyl PGI.sub.2 methyl ester.
5,6,7-trinor-4,8-int er-m-phenylene-16,17,18,19,20-pentanor-15-cyclohexyl PGI.sub.2 (N-ethyl) carboxamide.
5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2.
5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 methyl ester.
5,6,7-trinor-4,8-inter-m-phenylene-.omega.-homo PGI.sub.2.
13,14-dihydro-5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2.
Dependencies are inferred from the claim text.