US 4,301,161 AGranted

Cephalosporin derivatives

AssigneeChugai Seiyaku Kabushiki Kaisha

InventorsNobuhiro Oi, Bunya Aoki, Teizo Shinozaki, Kanji Moro, Isao Matsunaga, Takao Noto, Toshiyuki Nebashi, Yusuke Harada, Hisao Endo, Takao Kimura, Hiroshi Okazaki, Haruki Ogawa, Minoru Shindo

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Abstract

Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.

Claims5

Dependent claims

A cephalosporin derivative represented by the formula ##STR13## wherein R.sub.1 is a hydrogen atom or a lower alkyl group;

R.sub.2 is a hydrogen atom or a hydroxyl group;
R.sub.3 is a hydroxyl group or a lower alkanoyloxyl group;
n is 2 or 3;
at least two of R.sub.3 are bonded to adjacent carbon atoms, the position of substituent R.sub.3 being selected from 3 to 5 position when R.sub.1 is a lower alkyl group and R.sub.3 is a hydroxyl group, and 2 to 6 position when R.sub.1 and R.sub.3 are other substituents;
R.sub.4 is a hydrogen atom;
and R.sub.5 is an acetoxyl group or a pharmaceutically acceptable salt thereof.

3 more elements

Dependencies are inferred from the claim text.