Blood substitute containing modified hemoglobin
AssigneeAjinomoto Co., Inc.
InventorsYuji Iwashita, Katsumi Ajisaka
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Abstract
A novel modified hemoglobin was prepared. The hemoglobin is coupled with a polyalkylene glycol or its derivative, and the products are useful as a blood substitute. The oxygen-carrying capacity of this hemoglobin is nearly equal to that of a native hemoglobin, and the residence time in the circulation is satisfactorily long.
Claims7
An oxygen carrying material which comprises hemoglobin attached by a chemical reaction to a polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, a copolymer of ethylene glycol with propylene glycol, an ether of one of the above polyethylene glycols with an alcohol having a carbon number of 1 to 16, an ester of one of the above polyalkylene glycols with a carboxylic acid having a carbon number of 2 to 18, and a dehydrated product of one of the above polyalkylene glycols with an amine having a carbon number of 1 to 18.
Dependencies are inferred from the claim text.