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US 4,301,118 AGranted
Protein concentrator
AssigneeSpectrum Medical Industries, Inc.
InventorsRoy T. Eddleman, Gregory F. Moran
Life of this patent
Estimating the term…
Abstract
A protein concentrator having a reservoir for holding a protein solution and a membrane positioned within the protein solution through which a portion of the solution passes. The membrane is held in the walls of a container assembly and a water soluble polymer is located on one side of the membrane to increase the concentration gradient through the membrane for concentrating the solution.
Claims11
A protein concentrator, comprising:
- means defining a reservoir for holding a protein solution;
- a cover assembly held within said reservoir;
- a semi-permeable membrane member having openings large enough to permit passage of water but having a molecule weight cut-off sufficient to prohibit the passage of at least some of the consituents of a protein solution, said membrane member being supported by said cover assembly and forming a tubular container positioned within the reservoir so that a protein solution held within the reservoir will contact the outer surface of the semi-permeable member and the inner surface of the semi-permeable member will not be exposed to the contents of the reservoir, the semi-permeable member being sealed to the container to prevent any portion of the protein solution from passing to the interior of the container without passing through the member;
- and
- a water soluble polymeric powder held within said membrane, said polymeric powder having a molecular size so that it will not pass through the semi-permeable membrane member, whereby when a protein solution is placed in the reservoir, the protein solution will contact the exterior surface of the semi-permeable membrane and a portion of the protein solution will pass through the membrane and dissolve a portion of the water soluble polymeric powder creating a concentration gradient across the membrane to increase the flux of the solution through the membrane and into the container thereby concentrating the protein solution in the reservoir.
2 more elements
Dependencies are inferred from the claim text.