Method and nozzle for nasal vaccination of immature mammals

A nasal nozzle for insertion into the nasal cavities of mammals having alar folds for introducing fluid pharmaceutical composition comprising:

• (a) a convex body continuously curving at radius of 0.5 to 1.0 inches from a wide portion to an apex, said convex body having an axis, the axial length of said convex body being 0.36 to 0.6 inches, the diameter of said wide portion measured perpendicular to said axis being 0.48 to 0.6 inches,
• (b) elongated tip means for pushing aside the alar fold of the mammal upon insertion of said nozzle into the nasal cavity projecting from said apex along said axis, said tip means having length of 0.12 to 0.24 inches and outside diameter of 0.05 to 0.20 inches,
• (c) a channel throughout said convex body and elongated tip means along said axis, said channel having decreasing area from a rear end of said channel to an outlet opening on an end of said elongated tip means, said outlet opening having diameter of 0.025 to 0.05 inches, said channel having non-uniform taper and having a rear section having uniform taper, an offset wherein the angle included between said offset and said axis is from 25.degree. to 45.degree., and a front section having uniform taper such that the cross-sectional area of said front section decreases by 25% to 45% per 1/4 inch of front section length, and
• (d) adapting means for attaching said nozzle to a container for dispensing a pharmaceutical composition through said channel.