Process for the preparation of preserved transplants

A method of preserving material suitable for use as a human transplant comprising contacting dura mater with fresh amounts of water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methyl-ethylketone and mixtures thereof so as to dehydrate said dura mater, and subsequently removing said solvent at a pressure of between 0.1 bar and 1.0 bar.

Dura mater which has been preserved for use as a human transplant by contacting said dura mater in a continuous manner with fresh amounts of a water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methylethylketone and mixtures thereof so as to dehydrate said dura mater, and subsequently removing said solvent at a pressure of between 0.1 bar and 1.0 bar.

A method of preserving material suitable for use as a human transplant comprising contacting a biological collagenous material without subdivision thereof at ambient temperatures in the absence of added water with fresh amounts of water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methylethylketone and mixtures thereof so as to dehydrate said material, and subsequently removing said solvent at a pressure of between 0.1 bar and 1.0 bar, the final water content of said material being from 5 to 10%.

A biological collagenous material which has been preserved for use as a human transplant by contacting said material without subdivision thereof at ambient temperatures in the absence of added water with fresh amounts of water-miscible organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, methylethylketone and mixtures thereof so as to dehydrate said material, and subsequently removing said solvent at a pressure of between 0.1 bar and 1.0 bar, the final water content of said material being from 5 to 10%.