US 4,298,601 A · Method and formulations for the treatment of obesity

Abstract

It has been discovered that the unfavorable effects observed in weight reduction treatments based on severe dietary restriction (less than 600 Kcals/day) or total fasting (as regards fat, carbohydrates and aminoacids) are avoided by the administration of aminoacids and carbohydrates in critical but much lower amounts than has been believed to be necessary. Nitrogen loss with aminoacid intake between about 15 g and 30 g per day is affected by carbohydrate intake. Nitrogen balance is maintained and ketosis and water retention are controlled when the daily intake includes, in addition to necessary minerals and vitamins, at least 15 g of aminoacids in the proportions required by man, and from 15 g to 75 g, preferably 30 g to 45 g, of carbohydrates, with a total caloric value of from 160 to about 600 Kcals, preferably less than 400 Kcals, very desirably less than 360 Kcals, and optimally in the range of from 180 to 360 Kcals. Formulations are described in which the least amount containing the minimum daily requirement of minerals also contains at least 15 g of aminoacids (as a monomeric aminoacid mixture or as natural protein) and from 15 g to 75 g, preferably from 30 g to 45 g, of carbohydrates, together with optional other constituents.

Claims42

Dependent claims

A dietary formulation for the treatment of obesity in man, which comprises:

(a) all the minerals required by man;
(b) material which is a source of aminoacids selected from at least one member of the class consisting of:
(i) a mixture of monomeric L-aminoacids, and
(ii) natural proteins, and
(iii) natural proteins reinforced with at least one monomeric L-aminoacid;
and (c) digestible carbohydrate;
characterized in that a smallest amount of the dietary formulation containing at least the minimum daily requirements of each of the minerals required by man, including at least 800 mg calcium, 800 mg phosphorus, 140 .mu.g iodine, 10 mg iron and 350 mg magnesium, also contains
(A) at least 15 g of said material which must include at least the minimum daily requirements for man of all the essential L-aminoacids required by man;
and
(B) from 15 g to 75 g of said carbohydrate;
and further characterized in that the total caloric value of said smallest amount of the dietary formulation is in the range of from 160 Kcals to 600 Kcals.

8 more elements

A low calorie dietary formulation which is effective in providing an individual who ingests on a daily basis nothin more than said formulation with the minimum daily amounts of all of the minerals and vitamins required by the individual, said formulation containing digestible carbohydrate and materials which are sources of all of the essential L-aminoacids and all of the essential minerals required by an individual and characterized in that said constituents are present in proportions such that an amount of the formulation which has a caloric value of 160 Kcals to 400 Kcals consists essentially of:

(A) at least 15 g of material which is a source of aminoacids and selected from at least one member of the group consisting of:
(i) a mixture of monomeric L-aminoacids;
(ii) natural proteins;
and (iii) natural proteins reinforced with at least one monomeric L-aminoacid;
said material including at least the minimum daily amounts of all the essential L-aminoacids required by an individual;
(B) 15 to 75 g of digestible carbohydrate;
(C) mineral-containing material in an amount effective to provide said minerals in said amounts, including at least 800 mg calcium, 800 mg phosphorus, 140 .mu.g iodine, 10 mg iron, 350 mg magnesium, and also nutritional amounts of sodium, potassium, manganese, copper, zinc, chloride, and sulfur;
(D) about 2.4 to about 3.8 g of fatty acid or material which is a source thereof;
and
(E) material which is a source of vitamins in an amount effective to provide an individual with at least the minimum daily amounts of all of his required vitamins, including at least 60 mg ascorbic acid (Vitamin C), 0.4 mg folic acid, 18 mg niacin, 1.7 mg riboflavin, 1.4 mg thiamin, 5000 i.u. Vitamin A, 2.0 mg Vitamin B.sub.6, 5.0 .mu.g Vitamin B.sub.12, 400 i.u. Vitamin D, and 30 i.u Vitamin E;
and
wherein the weight ratio of said material of (A) above to said digestible carbohydrate is in the range of 1:1 to 1:5.

9 more elements

Dependencies are inferred from the claim text.

Method and formulations for the treatment of obesity

Life of this patent

Method and formulations for the treatment of obesity

Life of this patent

Abstract

Claims42