2,3-Dihydro-6,7-disubstituted-5-(acyl)benzofuran-2-carboxylic acids

A compound of the formula ##STR8## wherein X is halo, methyl or hydrogen;

• Y is halo or methyl;
• X and Y can be combined to form a hydrocarbylene radical of from 3 to 4 carbon atoms;
• R is selected from the group consisting of phenyl, p-methoxy phenyl, p-chlorophenyl, and
• the non-toxic pharmaceutically acceptable salt, ester and amide derivative thereof.

A pharmaceutical composition useful in the treatment of edema associated with hypertension comprising a therapeutically effective amount of a compound of the formula of ##STR9## wherein X is halo, methyl or hydrogen;

• Y is halo or methyl,
• X and Y can be combined to form a hydrocarbylene radical of from 3 or 4 carbon atoms,
• R is phenyl or mono or disubstituted phenyl wherein the substituent is halo, methyl, trifluoromethyl or methoxy and
• the non-toxic pharmaceutically acceptable salt, ester and amide derivative thereof and a pharmaceutically acceptable carrier.

A pharmaceutical composition useful in the treatment of edema associated with hypertension comprising a therapeutically effective amount of a compound of the formula:

• ##STR10## wherein X is chloro;
• Y is chloro;
• and R is selected from the group consisting of phenyl, p-methoxy phenyl, p-chlorophenyl, and
• the non-toxic pharmaceutically acceptable salt, ester and amide derivative thereof and a pharmaceutically acceptable carrier.

A method of treatment of edema associated with hypertension comprising the administration of a therapeutically effective amount in unitary dosage form of a compound having the formula of:

• ##STR11## wherein X is halo, methyl or hydrogen;
• Y is halo or methyl;
• X and Y can be combined to form a hydrocarbylene radical of from 3 to 4 carbon atoms;
• R is phenyl or mono or disubstituted phenyl wherein the substituent is halo, methyl, trifluoromethyl or methoxy and
• the non-toxic pharmaceutically acceptable salt, ester and amide derivative thereof.

A method of treatment of edema associated with hypertension comprising the administration to a patient of from 0.01 mg. to 10 mg./kg of body weight of the patent of a compound having the formula:

• ##STR12## wherein X is chloro;
• Y is chloro;
• and
• R is selected from the group consisting of phenyl, p-methoxy phenyl, p-chlorphenyl, benzyl and p-chlorobenzyl and
• the non-toxic pharmaceutically acceptable salt, ester and amide derivative thereof.