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AssigneeTeijin Limited
InventorsYoshiki Suzuki, Hiroshi Ikura, Gentaro Yamashita, Tsuneji Nagai
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A powdery pharmaceutical composition and a powdery preparation in unit dosage form for application to the mucosa of the nasal cavity, at least about 90% of which consists of particles having an effective particle diameter of about 20 to about 250 microns, said composition comprising a lower alkyl ether of cellulose having a viscosity, determined at about 37.degree. C. for a 2% aqueous solution thereof, of at least about 5 centipoises and a pharmaceutically effective amount of a drug; and a method for treating or preventing a human nasal disease, which comprises administering a powdery preparation in unit dosage form to the nasal cavity of a human being requiring treatment or prevention of a nasal disease through his nostrils.
A powdery pharmaceutical composition for application to the mucosa of the nasal cavity, at least about 90% of which consists of particles having an effective particle diameter of about 20 to about 250 microns, said composition comprising a lower alkyl ether of cellulose selected from the group consisting of methyl cellulose, hydroxy-lower alkyl cellulose and carboxylate formed between alkali metals and carboxy-lower alkyl cellulose wherein said lower alkyls have 2 or 3 carbon atoms, said lower alkyl ether of cellulose having a viscosity, determined at about 37.degree. C. for a 2% aqueous solution thereof, of at least about 5 centipoises and a pharmaceutically effective amount of a drug selected from the group consisting of a steroidal anti-inflammatory agent, a nonsteroidal anti-inflammatory agent, an anti-histaminic agent, an anti-allergic agent and a vasoconstrictor.
A powdery preparation in unit dosage form for application to the mucosa of the nasal cavity, at least about 90% by weight of which consists of particles having an effective particle diameter of about 20 to about 250 microns, said powdery preparation comprising a lower alkyl ether of cellulose selected from the group consisting of methyl cellulose, hydroxy-lower alkyl cellulose and carboxylate formed between alkali metals and carboxy-lower alkyl cellulose wherein said lower alkyls have 2 or 3 carbon atoms, said lower alkyl ether of cellulose having a viscosity, determined at about 37.degree. C. for a 2% by weight aqueous solution thereof, of at least about 5 centipoises and a pharmaceutically effective amount of a drug selected from the group consisting of a steroidal anti-inflammatory agent, a nonsteroidal anti-inflammatory agent, an anti-histaminic agent, an anti-allergic agent and a vasoconstrictor.
A method for treating for preventing a human nasal disease, which comprises administering a powdery preparation in unit dosage form to the nasal cavity of a human being requiring treatment or preventing of a nasal disease through his nostrils, thereby adhering said powdery preparation to the nasal mucosa, said powdery preparation comprising a lower alkyl ether of cellulose selected from the group consisting of methyl cellulose, hydroxy-lower alkyl cellulose and carboxylate formed between alkali metals and carboxy-lower alkyl cellulose wherein said lower alkyls have 2 or 3 carbon atoms, said lower alkyl ether of cellulose having a viscosity, determined at about 37.degree. C. for a 2% by weight aqueous solution thereof, of at least about 5 centipoises and a pharmaceutically effective amount of an agent for treating or preventing the nasal disease selected from the group consisting of a steroidal anti-inflammatory agent, a nonsteroidal anti-inflammatory agent, an anti-histaminic agent, an anti-allergic agent and a vasoconstrictor, at least about 90% by weight of said preparation consisting of particles having an effective particle diameter of about 20 to about 250 microns.
Dependencies are inferred from the claim text.