Lyophilized hydrocolloio foam
AssigneeE. R. Squibb & Sons, Inc.
InventorsJohn M. Pawelchak, Yu-Chang J. Wang, Anthony L. LaVia
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Abstract
A lyophilized foam sponge product having medically useful hemostatic and adhesive properties formed from the hydrocolloids, gelatin, pectin, and sodium carboxymethylcellulose and having a density of from about 0.01 to about 0.10 grams/cc. The gelatin is present at from about 20% to about 80% by weight of the final product and the pectin and sodium carboxymethylcellulose are each present at from about 10% to about 50% by weight of the final product. The product is prepared by forming an aqueous colloidal dispersion of hydrocolloids, aerating or foaming, freezing, and lyophilizing.
Claims30
A medically useful lyophilized sponge product having a density of from about 0.01 to about 0.10 gm/cc, said sponge product comprising a mixture of the hydrocolloids, gelatin, pectin, and sodium carboxymethylcellulose, said pectin and sodium carboxymethylcellulose each being at from about 10% to about 50% by weight of the final product and said gelatin being present at from about 20% to about 80% by weight of the final product.
A process for preparing a medically useful sponge product comprising
- (a) forming a dry blend comprising a mixture of the hydrocolloids, gelatin, pectin, and sodium carboxymethylcellulose said pectin and sodium carboxymethyl cellulose each being present at from about 10% to about 50% by weight of product and said gelatin being present at from about 20% to about 80% by weight of the product;
- (b) adding said dry blend to water with agitation to form a colloidal dispersion said dispersion having a solids content of from about 1% to about 20% by weight;
- (c) aerating or foaming the colloidal dispersion so that its volume increases by about 10% to about 600%;
- (d) pouring said aerating or foaming dispersion into a suitable receptacle;
- (e) freezing;
- and
- (f) lyophilizing.
Dependencies are inferred from the claim text.