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US 4,291,168 AGranted
Silylated indanyloxyacetates
AssigneeMead Johnson & Company
InventorsPorter C. Johnson, William L. Matier
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Abstract
Indanyloxy compounds having 2-alkynyl substituents which exhibit diuretic, saluretic, and uricosuric activity are described. The compounds are obtained according to a process involving selective etherification of a 5-hydroxyindanone followed by alkynylation with a silylated alkynyl bromide to provide novel silylated intermediates which are hydrolyzed to indanyloxy compounds such as (6,7-dichloro-1-oxo-2-phenyl-2-propargyl-5-indanyloxy)acetic acid.
Claims7
A silylated compound of Formula IV ##STR13## wherein n is 1 or 2;
- X is halo;
- R.sub.1 is phenyl or p-halophenyl;
- and
- R.sub.3 is lower alkyl.
1 more element
Dependencies are inferred from the claim text.