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US 4,291,166 AGranted
Pharmaceutically active 6,9-thiaprostacyclin analogs and derivatives thereof
AssigneeResearch Corporation
InventorsKyriacos C. Nicolaou, William E. Barnette, Ronald L. Magolda
Life of this patent
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Abstract
Stable biologically active 6,9 .alpha.-thiaprostacyclin derivatives having the formula ##STR1## wherein X represents >S, >SO or >SO.sub.2 ; Y represents (E) and (Z)-->C.dbd.CH--CH.sub.2 CH.sub.2 CH.sub.2 COOR, (E)-->CH--CH.dbd.CH--CH.sub.2 CH.sub.2 COOR or >CH--CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 COOR; and R represents hydrogen, a pharmaceutically acceptable cation or a pharmaceutically acceptable lower alkyl group.
Claims15
Biologically active 6,9.alpha.-thiaprostacyclin derivatives having the formula:
- ##STR22## wherein X represents >S, >SO or >SO.sub.2 ;
- Y represents (E) and (Z) >C.dbd.CH--CH.sub.2 CH.sub.2 CH.sub.2 COOR;
- (E)>CH--CH.dbd.CH--C.sub.2 CH.sub.2 COOR or >CH--CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 COOR;
- and
- R represents a pharmaceutically acceptable cation or a pharmaceutically acceptable lower alkyl group.
2 more elements
Dependencies are inferred from the claim text.