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US 4,291,160 AGranted
7-(1,3-Dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivatives
AssigneeRichardson-Merrell Inc.
InventorsBoyd L. Harrison, Joseph E. Dolfini
Life of this patent
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Abstract
Novel 7-(1,3-dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivatives are described which possess useful antibacterial properties.
Claims4
A 7-(1,3-dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivative having the formula ##STR9## wherein R.sub.1 is selected from the group consisting of 5-methyl-1,3,4-thiadiazol-2-ylthio, 1-methyl-1,2,3,4-tetrazol-5-ylthio and 1,2,3-triazol-4-ylthio;
- R.sub.2 is selected from the group consisting of hydrogen, t-butyl, 2,2,2-trichloroethyl, benzhydryl, formyloxymethyl and alkanoyloxymethyl in which the alkanoyl group contains from 2 to 5 carbon atoms;
- R.sub.3 is selected from the group consisting of alkyl having from 1 to 4 carbon atoms, carboxymethyl, alkoxycarbonyl and (alkoxycarbonyl)methyl wherein the alkoxy group has from 1 to 4 carbon atoms, halomethyl, benzyl and substituted benzyl wherein the benzyl substituent is methoxy or halo;
- and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.