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US 4,291,133 AGranted
Nonthrombogenic polymer surface
OwnerVaclav Horak, Jiri Janatainventors
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Abstract
Polymer surfaces which are rendered nonthrombogenic are disclosed. Polymers, including hydrophobic polymers, which can be swollen by selected solvents, are rendered nonthrombogenic by absorbing into the surface of said polymers pendant aliphatic side chains which are attached to a linear polymer having reactive pendant groups which are negatively charged or which may be reacted with compounds having a negative charge, such as heparin. The compounds absorbed into the substrate surface have multi-point attachment to the surface.
Claims10
A surface-modified polymeric substrate comprising:
- a polymeric hydrophobic substrate swellable by selected solvents:
- and
- a branched-chain polymer having a substantially linear hydrocarbon backbone, substantially linear hydrocarbon aliphatic side chains spaced along said backbone and a plurality of pendant reactive groups which are negatively charged or which may be reacted with compounds having a negative charge depending from said backbone, said linear aliphatic side chains having not over twenty (20) carbon atoms and being substantially embedded in said polymeric substrate.
Dependencies are inferred from the claim text.