Pharmaceutical compositions containing urea
AssigneePhares Pharmaceutical Research N.V.
InventorsSteven Leigh, Peter J. Ayres
Life of this patent
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Abstract
Pharmaceutical compositions for application topically or by suppository comprise: (a) a medicament, preferably protected from degradation by moisture by being presented in small particles of a waxy material, (b) from 5% to 40% of an inclusion compound of urea with a straight-chain aliphatic compound, preferably a fatty acid or alcohol, (c) up to 50% of an inert insoluble powder such as starch, (d) from 25% to 90% of an inert carrier, components (a), (b) and (c) being dispersed in (d). The compositions have good storage stability and a smooth texture.
Claims8
A pharmaceutical composition for application topically or by means of a suppository comprising:
- (a) an effective concentration of a medicament for administration topically or by means of a suppository,
- (b) from 5% to 40% of small particles of an inclusion compound of urea with at least one straight-chain aliphatic compound having from 4 to 30 carbon atoms per molecule,
- (c) up to 50% of a powder that is inert to and insoluble in the remaining ingredients,
- (d) from 25% to 90% of a carrier material which does not dissolve or react with any of components (a), (b), or (c), optionally together with a thickening agent to provide a composition of the desired consistency,
- components (a), (b) and (c) being dispersed in component (d).
Dependencies are inferred from the claim text.