6,7-Disubstituted-2 or 2,2-substituted-5-substituted-1-indanones
AssigneeMerck & Co., Inc.
InventorsOtto W. Woltersdorf, Jr., Edward J. Cragoe, Jr.
Life of this patent
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Abstract
This invention relates to a new class of chemical compounds which can be described generally as 6,7-disubstituted-2 or 2,2-substituted-5-substituted-1-indanones. These compounds are effective diuretic and saluretic agents.
Claims6
A compound of the formula ##STR4## wherein X is halo or methyl
- Y is halo or methyl;
- R is
- hydroxy ethyl;
- 2-oxo propyl;
- 1,2-dihydroxypropyl, provided that X or Y is not methyl;
- amino ethyl;
- formyl methyl;
- dialkoxy (C.sub.1-6) methyl;
- or ##STR5## R.sup.1 is hydrogen or C.sub.1-6 alkyl;
- R.sup.2 is C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, aryl, aralkyl or substituted aryl wherein the substituent is halo or C.sub.1-3 alkyl.
A compound of the formula ##STR6## wherein X and Y are chloro;
- R is 2-oxy propyl or hydroxy ethyl;
- R.sup.1 is C.sub.1-6 alkyl;
- R.sup.2 is C.sub.3-6 cycloalkyl or phenyl.
A pharmaceutical composition useful in the treatment of edema and hypertension which comprises a anti-edema and hypertensive effective amount of a compound of the formula ##STR7## wherein X is halo or methyl
- Y is halo or methyl;
- R is
- hydroxy ethyl;
- 2-oxo propyl;
- 1,2-dihydroxypropyl, provided that X or Y is not methyl;
- amino ethyl;
- formyl methyl;
- dialkoxy (C.sub.1-6) methyl;
- or ##STR8## R.sup.1 is hydrogen or C.sub.1-6 alkyl;
- R.sup.2 is C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, aryl, aralkyl or substituted aryl wherein the substituent is halo or C.sub.1-3 alkyl
- and a pharmaceutically inert carrier.
A method of treating edema and hypertension which comprises administering to a patient in need of such treatment a anti-edema and hypertensive effective amount of a compound of the formula:
- ##STR9## wherein X is halo or methyl
- Y is halo or methyl;
- R is
- hydroxy ethyl;
- 2-oxo propyl;
- 1,2-dihydroxypropyl, provided that X or Y is not methyl;
- amino ethyl;
- formyl methyl;
- dialkoxy (C.sub.1-6) methyl;
- or ##STR10## R.sup.1 is hydrogen or C.sub.1-6 alkyl;
- R.sup.2 is C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, aryl, aralkyl or substituted aryl wherein the substituent is halo or C.sub.1-3 alkyl.
Dependencies are inferred from the claim text.