7-(Oxoalkyl)-1,3-di-n-iso-propyl xanthines and their production
AssigneeJohann A. Wulfing
InventorsGunther Brenner, Joachim Goring, Eskendar Ali Khan, Oskar Rohte, Manfred Tauscher
Life of this patent
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Abstract
7-(Oxoalkyl)-1,3-dialkyl xanthines whose substituents in the 1- and 3-positions are alkyl groups of 2 to 6 carbons, cyclohexyl, alkoxyalkyl or hydroxyalkyl, such as 7-(3-oxobutyl)-1,3-di-n-butylxanthine, are effective vasodilators, having a marked activity in promoting blood flow through skeletal muscle, while at the same time exhibiting low toxicity.
Claims18
7-(1-methyl-3-oxobutyl)-1,3-di-isopropyl xanthine.
7-(3-oxobutyl)-1,3-di-n-isopropyl xanthine.
7-(5-oxohexyl)-1,3-di-isopropyl xanthine.
7-(1-methyl-2-oxopropyl)-1,3-di-isopropyl xanthine.
A pharmaceutical composition useful for promoting the flow of blood through skeletal muscles in humans and animals which comprises a therapeutically effective amount of 7-(1-methyl-3-oxobutyl)-1,3-di-isopropyl xanthine in combination with a pharmaceutically acceptable carrier.
A pharmaceutical composition useful for promoting the flow of blood through skeletal muscles in humans and animals which comprises a therapeutically effective amount of 7-(3-oxobutyl-1,3-di- n-isopropyl xanthine in combination with a pharmaceutically acceptable carrier.
A pharmaceutical composition useful for promoting the flow of blood through skeletal muscles in humans and animals which comprises a therapeutically effective amount of 7-(5-oxohexyl)-1,3-di-isopropyl xanthine in combination with a pharmaceutically acceptable carrier.
A method of promoting the flow of blood through skeletal muscles in humans and animals which comprises administering to a human or animal in need thereof a therapeutically effective amount of 7-(1-methyl-3-oxobutyl)-1,3-di-isopropyl xanthine.
A method of promoting the flow of blood through skeletal muscles in humans and animals which comprises administering to a human or animal in need thereof a therapeutically effective amount of 7-(3-oxobutyl)-1,3-di-n-isopropyl xanthine.
A method of promoting the flow of blood through skeletal muscles in humans and animals which comprises administering to a human or animal in need thereof a therapeutically effective amount of 7-(5-oxohexyl)-1,3-di-isopropyl xanthine.
Dependencies are inferred from the claim text.