Pharmaceutical compositions comprising trimethoprim and N-ethyl-.gamma.-pyridone-3-carboxylic acid derivatives
AssigneeSigma-Tau Industrie Farmaceutiche Riunite S.p.A.
InventorAlfio Bertolini
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Abstract
Pharmaceutical compositions comprising trimethoprim and a N-ethyl-.gamma.-pyridone-3-carboxylic acid derivative, such as nalidixic, oxolinic or piromidic acid, are more effective than previously known trimethoprim-containing compositions for the treatment of infections affecting the urinary tract. Trimethoprim and the foregoing acid derivatives unpredictably show a noticeable synergistic effect.
Claims2
A pharmaceutical composition for treating bacterial infections of the urinary tract, comprising
- (a) an effective amount of trimethoprim,
- (b) an effective amount of, oxolinic acid or pharmaceutically acceptable salt thereof, and
- (c) an inert excepient therefor, the weight ratio of trimethoprim to oxolinic acid of 1:5.
A therapeutical method for treating a patient suffering from a bacterial infection of the urinary tract, which comprises administering to said patient
- (a) from 2 to 8 mg/kg/day of trimethoprim, and
- (b) from 10 to 40 mg/kg/day of oxolinic acid, in a weight ratio of trimethoprim to oxolinic acid of 1:5.
Dependencies are inferred from the claim text.