Antibiotic BM123.nu. pamoate complexes
AssigneeAmerican Cyanamid Company
InventorsMartin Tobkes, Murray Dann, Irving Klothen, Larry D. Spicer, David R. Williams
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Abstract
This disclosure describes reversible complexes made from antibiotic trans-BM123.nu. and water soluble pamoate salts and a process for preparing same. These highly stable complexes are useful as animal feed supplements which significantly enhance the growth rate of animals and poultry.
Claims12
A process of recovering an antibiotic trans-BM123.nu. pamoate complex from a fermentation whole harvest mash containing the antibiotic trans-BM123.nu. which comprises the steps of:
- (a) producing a fermentation liquor by clarifying the whole harvest mash;
- and
- (b) adding a water soluble pamoate salt selected from the group consisting of ammonium pamoate, alkali metal pamoate, alkaline earth metal pamoate and combinations thereof while maintaining the liquor at a pH of from 4.0 to 8.0 by addition of a pharmacologically acceptable acid, or base, and
- (c) removing the precipitated antibiotic trans-BM123.nu. pamoate complex;
- and
- (d) drying the antibiotic trans-BM123.nu. pamoate complex.
A process for the production of a dried fermentation harvest mash solids animal feed supplement containing an antibiotic trans-BM123.nu. pamoate complex which comprises the steps of:
- (a) adding a water soluble pamoate salt selected from the group consisting of ammonium pamoate, alkali metal pamoate, alkaline earth metal pamoate and combinations thereof to a fermentation whole harvest mash containing antibiotic trans-BM123.nu. while simultaneously maintaining the pH from 4.0 to 8.0 by adding a pharmacologically acceptable acid, or base;
- and
- (b) removing the harvest mash solids together with the precipitated antibiotic trans-BM123.nu. pamoate complex;
- and
- (c) drying the mixture of mash solids and antibiotic trans-BM123.nu. pamoate complex.
Dependencies are inferred from the claim text.