Method for treating tumors using cis-diammineplatinum (II) organophosphate complexes
AssigneeEngelhard Minerals & Chemicals Corporation
InventorsJames D. Hoeschele, Alan R. Amundsen
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Abstract
Cis-diammineplatinum (II) organophosphate complexes where the organophosphate moiety is a glycerophosphate or a monosaccharide phosphate moiety are prepared by reaction of cis-diaquodiammineplatinum (II) salts with alkali metal organophosphates. The resulting complexes possess pronounced anti-tumor activity and low toxicity; consequently, they have high therapeutic indices.
Claims11
A method for treating malignant tumors selected from the group consisting of sarcoma 180 ascites, lymphoid leukemia L1210 and lymphocytic leukemia P388 in a mammal afflicted therewith, which comprises administering to said mammal an effective amount of a platinum(II) organophosphate complex for treating said tumors, said complex having a structure of the formula:
- [Pt(NH.sub.3).sub.2 (R.sup.1 (OPO.sub.3).sub.z).sub.y ]
- wherein R.sup.1 (OPO.sub.3).sub.z is an organophosphate moiety in which R.sup.1 is selected from the group consisting of the monovalent residue of glycerol and the monovalent or divalent residue of a monosaccharide;
- y is an integer having a value of from about 0.4-0.9;
- and z is 1 or 2.
Dependencies are inferred from the claim text.