Technetium-labelled diagnostic agent for the examination of the RES
AssigneeHoechst Aktiengesellschaft
InventorsHelmut Strecker, Michael Molter, Gerhard Kloss, Eberhard Schickel
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Abstract
A process is disclosed for the preparation of a diagnositc agent for scanning the RES, in particular the liver, by mixing the sodium salt of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone in aqueous solution with tin(II) salt, adjusting the solution to a pH between 4 and 9, optionally lyophilizing the mixture and adding .sup.99m Tc-pertechnetate in physiological saline solution.
Claims7
A process for the preparation of a diagnostic agent for scanning the RES, which comprises mixing the sodium salt of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone in an aqueous solution with tin(II) salt in a molar ratio of 15:1 to 110:1, adjusting the resulting solution to a pH between 4 and 9, and afterwards adding from 0.1 to 100 mCi of .sup.99m Tc-pertechnetate in 1 to 10 ml of physiological saline solution.
A process as defined in claim 8 wherein the concentration of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylaminomethylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone is in the range of from 0.1 to 200 mg/ml.
A diagnostic agent for visualizing the RES consisting essentially of a colloidal 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid-tin(II).sup.99m Tc compound or colloidal 1-phenyl-2,3-dimethyl-pyrazolone-tin(II).sup.99m Tc compound in physiologically saline solution.
Dependencies are inferred from the claim text.