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US 4,290,975 AGranted
N-Sulfonyl amine-mediated sulfamation of amines
OwnerGrant E. DuBoisinventor
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Abstract
Primary amines are selectively sulfamated by the two-step process of: A. Contacting the amine in liquid phase at low to moderate temperatures with catechol sulfate thereby forming a catechol sulfate addition product, and B. Hydrolyzing the catechol sulfate addition product to the desired sulfamate by contacting it at elevated temperature with a strong base in liquid phase.
Claims10
The process for sulfamation of primary organic amine which comprises the steps of:
- (a) contacting said primary organic amine in liquid phase with catechol sulfate at a low to moderate temperature for a period of from about 1 hour to about 72 hours, thereby forming an O-2-hydroxyphenyl sulfamic acid ester, and
- (b) hydrolyzing the O-2-hydroxyphenyl sulfamic acid ester by contacting it with a strong base at a temperature of from 50.degree. C. to 200.degree. C. for from 1 minute to 12 hours, thereby forming the sulfamic acid salt corresponding to said strong base.
Dependencies are inferred from the claim text.