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US 4,290,966 AGranted
Process for the preparation of traumatin
AssigneeMerck & Co., Inc.
InventorsJeannette E. Brown, Edward F. Rogers, Donald W. Graham
Life of this patent
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Abstract
Traumatin, 12-oxo-trans (E) -10-docecenoic acid, is prepared from 10-oxomethyldecanoate by reaction with (triphenylphosphoranylene)acetaldehyde to form 12-oxomethyldodecenoate; blocking the 12-oxo group; hydrolyzing the ester group; and deblocking the 12-oxo group.
Claims6
A process for the preparation of traumatin which comprises:
- (a) treating 10-oxomethyldecanoate in a non-polar organic solvent with (triphenylphosphoranylene)acetaldehyde to obtain 12-oxomethyldodecenoate;
- (b) treating the product of Step (a) with ethylene glycol in a non-polar organic solvent to obtain methyl 11-(1,3-dioxalane-2-yl)-10-undecenoate;
- (c) hydrolyzing the product of Step (b) to obtain 11-(1,3-dioxalane-2-yl)-10-undecenoic acid;
- and
- (d) hydrolyzing the product of Step (c) to obtain traumatin.
2 more elements
Dependencies are inferred from the claim text.